My suggestion is, if what is being signed in class is not vital to the story, insert something else interesting to be happening for the audience at the same time. You could be setting up a subplot by showing two students passing notes or signing to each other below eye level (or under their desks). You could have a couple visiting characters, who don't "speak" sign-language but are waiting for class to end or for a chance to speak to the professor, they could be talking to each other on the side, and inter-cut it with shots of the professor signing away to the class [as background].
Or if the professor is able to multi-task, they could sign things to the class as they hold a speaking conversation with someone else. And in that case, you could easily explain it, for example: "well can you really talk right now, i mean aren't you teaching a class?" "oh yeah, it's no problem, I'm only teaching them to sign colors. You don't have to concentrate on stuff like that. When i start teaching them ______, then you'll have to wait until after class."
And if what is being signed in a scene is actually vital to the story: then you can have the person verbalize while they sign it, or utilize having to explain it to another character who doesn't understand enough sign, or simply use subtitles. It's your preference, and it really might work well to change-up which you use based on the type of scene or not.
Also, it's not always important if the audience understands what is signed. It can make things interesting and add dimension or emphasis his/her job, just so long as it's not confusing to the audience. A confused audience is a lost audience.
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