Yes, I worry about paneling, but not until I draw a rough (think stick figures) version of the story.
When writing the script, I do it as a screenplay and completely ignore panels. I find it's much easier and better to draw the layout than write it. I sometimes may note down a camera angle or that it's an establishing shot in the script, but nothing beyond that.
Then when I do the rough, I can put it all together and see how it fits on the page and how the panels relate to each other. Some motives work better in tall panels, some in wide and some work better without a border and so on. I find the layout of the whole page to be very important, and it's hard to get a clear idea of that by writing a description of it. I may tweak the dialog to make the whole thing fit better together on the page. I generally try to either condense or extend scenes so that surprise elements happen when you turn the page and not in the middle of a spread. Doing a rough version is very fast, and lets me throw around different ideas as to how to tell the story. It's easier to throw away pages that are not working at this stage, then later on.
I would probably do the same if I weren't drawing the comics myself, as long as I had an artist with a good grasp of storytelling.
So for me the process would be something like: idea, outline, script, rough stick figure, pencil drawing and final rendered version (ink/color/paint whatever). The layout, text placement and angles are all more or less set in the rough version.
That said. I should be working on my script now...only three pages done so far. :)
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